Figure 1 (Diff Quik, 100X)
Figure 2 (Diff Quik, 400X)
Figure 3 (H&E, 400X)
Figure 4 (Pap, 400X)
Interesting Case
Contributors:
Dorota E. Rudomina, MBA, CT (ASCP)
Bhavna Kumar, MD
Memorial Sloan-Kettering Cancer Center, New York, New York
Clinical history:
An 81 year old female presented with a palpable right-sided neck/thyroid mass. A CT scan showed a mass, approximately 7.5 cm. in greatest dimension, with tracheal deviation. Due to her pre-existing medical problems, the patient was kept on observation but the mass was noted to be increasing in size. A fine needle aspiration biopsy of the mass was performed, followed by a total thyroidectomy a couple of months later.
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Figure 1 (Diff Quik, 100X) |
Figure 2 (Diff Quik, 400X) |
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Figure 3 (H&E, 400X) |
Figure 4 (Pap, 400X) |
Cytologic findings:
The specimen was very cellular and contained a striking monomorphous cell population. (Figure 1) Many single cells as well as syncytial tissue fragments were present. There was a predominant micro-follicular growth pattern with few interspersed papillary clusters. (Figure 2) Most of the cells were large, polygonal to oval in shape, with well-defined cell borders. (Figure 3) The cytoplasm was abundant with eosinophilic granules. The chromatin was finely granular and few nuclear grooves were identified. Macronucleoli were common and occasional larger cells with binucleation were also present. (Figure 4) No colloid was appreciated.
Cytologic diagnosis: Click here!